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Through the electrophile response element (EpRE), ERK1/2 and p38MAPK signaling pathways actively contribute to upregulation of GGT promoter 5 (GP5) activity in response to 4-hydroxynonenal (HNE) (43)

It is essential for cellular defense against oxidative stress and is involved in various metabolic and enzymatic processes

Unlike the GLP-1 drugs that reshaped obesity treatment over the past decade, retatrutide targets three hormone receptors simultaneously

The V-rescale thermostat with two coupling groups was used to maintain the temperature of the system, and the Parrinello-Rahman barostat was used to maintain the pressure of the system