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The canonical Wnt pathway, which includes low density lipoprotein receptor-related protein 5/6, -catenin, GSK-3, and T cell factor (42), promotes osteoblast differentiation and maturation (43)
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Additionally, GIP directly stimulates lipogenesis, while GLP-1 indirectly promotes lipolysis, collectively maintaining healthy adipocytes, reducing ectopic fat distribution, and increasing the production and secretion of adiponectin from adipocytes
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