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Funding This work was supported by Science and Technology Key Program of Hunan Province Grants (2016SK2066), Key Projects of Hunan Health Committee (B2017207), Hunan Province Chinese Medicine Research Program Grants (201940), Changsha City Science and Technology Program Grants (kq1801144), Changsha Central Hospital Affiliated to University of South China Foundation of key Program (YNKY201901), Hunan Province Foundation of High-level Health Talent (225 Program), and Science and Technology Key Program of Hunan Provincial Health Committee (20201904)