glutathione peroxidase 3 is a potential biomarker for konzo Glutathione Peroxidase 3 - an

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Even in people without overt deficiency, B12 injections can correct subclinical insufficiency more rapidly than oral supplementation

After its synthesis, GSH is delivered to some intracellular compartments, including mitochondria, endoplasmic reticulum, nucleus, and to the extracellular space (e.g., blood plasma and bile) for utilization by other cells and tissues (Forman et al., 2009)

In NPCs, SOD2-dependent redox imbalance sensitizes cells to lipid peroxidation, whereas compensatory mitophagy is detectable but often insufficient to fully restore mitochondrial quality control (34)