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For example, chronic intranasal administration of house dust mite (HDM) antigen led to impaired spatial memory and depression-like behaviors in mice

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In the central nervous system, agents like exedin-4 and liraglutide reduce neuroinflammation by inhibiting microglial activation and cytokine production (IL-1, IL-6, TNF- ), while preserving neuronal integrity and preventing cognitive dysfunction associated with sepsis