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However, patients should be advised to report symptoms suggestive of liver injury, including: Persistent nausea or vomiting unrelated to expected GI side effects Right upper quadrant abdominal pain (which may also indicate gallbladder disease, a known risk with GLP-1 therapy) Jaundice (yellowing of skin or eyes) Dark urine or pale stools Unexplained fatigue or malaise Clinicians should maintain a low threshold for investigating these symptoms with comprehensive liver function tests, including ALT, AST, alkaline phosphatase, bilirubin, albumin, and INR/prothrombin time

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Compared with individuals with the E3/3 genotype, E2 carriers have a 20 % lower risk of coronary heart disease, and E4 carriers have a slightly higher risk [97]

doi: 10.1111/dom.14551 154 TanakaKOkadaYTokutsuATanakaY