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It is not really understood why cancers overexpress ALDOA over ALDOB, but it is reasonable to assume that this is because ALDOA exhibits much higher affinity for fructose-1,6-bisphosphate than ALDOB, and it does not require cleaving fructose-1-phosphate that originated from fructose, which is usually a property of ALDOB residing in the liver, the organ that will convert much of ingested fructose to glycolytic intermediates anyway 118

Furthermore, we review the results from the currently available large-scale cardiovascular outcome trials and the use of GLP1RAs for other indications