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The widths of these CIs were assumed to be representative of the CIs for the ratios between IcoSema and icodec alone (for icodec) and between IcoSema and semaglutide alone (for semaglutide) with respect to the primary endpoint in the current study (area under the concentration-time curve from zero to last quantifiable observation after a single dose

Vitamin B12 Medicine Interactions Chloramphenicol: bacteriostatic antibiotic can interfere with red blood cell response to supplemental Vit B12 Proton pump inhibitors: omeprazole and lansoprazole, etc., slow gastric acid release and may interfere with VIt B12 absorption from food H2-receptor antagonists: cimetidine, famotidine and ranitidine slow the release of hydrochloric acid into the stomach and interfere with Vitamin B12 absorption from food Metformin: might reduce absorption of Vitamin B12 due to altered intestinal motility, increased bacterial overgrowth, etc

Ethical Approval This study was performed in accordance with relevant guidelines and regulations, including the principles of the Helsinki Declaration of 1964 and its later amendments