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confirmed that TMAO, as a chemical molecular chaperone, has a protective effect on patients with early-stage asthma by reducing the expression of C/EBP homologous protein (CHOP) and resolving the maladaptive UPR signature (71)

Chronic persistent hypoxia is recurrent in chronic lung diseases where O 2 levels remain constantly low, while chronic IH is characteristic of obstructive sleep apnea, characterized by an intermittent pattern of episodes of hypoxia and reoxygenation [133]

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