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Studies conducted on the haploid cell line KBM7 through insertional mutagenesis indicate that the inactivation of LPCAT3 and ACSL4 allows cells to become resilient against RSL3 and ML162, two GPX4 inhibitors (20)

The dominant species are O 2 and its dismutation product H 2 O 2 , while nuclear OH arises secondarily through metal-catalyzed reactions in proximity to DNA or histone-bound metal centers