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Neurodegenerative Diseases Neurodegenerative diseases, such as Parkinsons (PD), Alzheimers (AD), amyotrophic lateral sclerosis (ALS), and Huntingtons, share several common features in pathogenesis, such as (i) the accumulation of abnormally aggregated proteins (pathological inclusions), (ii) oxidative damage and (iii) mitochondrial dysfunction [172]

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In our study, we observed moderately reduced HR estimates in the main per-protocol analysis, as well as in the analysis restricted to maximum 5 years of follow-up (HR 0.75

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