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Tirzepatide, the dual GLP-1/GIP agonist marketed as Zepbound for obesity and Mounjaro for type 2 diabetes, is currently the most potent approved agent in the class

however, it is also a precursor for the intracrine biosynthesis of potent androgens and estrogens in peripheral tissues that express the relevant steroidogenic enzymes, such as the skin (Labrie et al., 2003