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mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

Note that most of this evidence comes from cell cultures and animal models, so it describes biological mechanisms rather than proven outcomes in people

Our goal has been to do enough proof-of-principle that people will accept that stapled peptides can get into cells and act on important targets

Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)