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10.1016/j.plaphy.2011.10.020 81 KogovsekP.Pompe-NovakM.BaeblerS.RotterA.GowL.GrudenK.et al
FIGURE 9 Summary and conclusions: Glutathione and early (premature) inflammaging Chronic inflammatory diseases especially those compromising the lower respiratory system (chronic obstructive pulmonary disease, lower respiratory infections, cystic fibrosis, idiopathic pulmonary fibrosis, acute respiratory distress syndrome), diseases compromising the cardiovascular system (atherosclerosis, ischemic heart disease, stroke, and others), many other systemic inflammatory diseases like diabetes (274, 275)
[9], [10] Age-related changes in cognitive function have a multifactorial origin, with proteasomal dysfunction potentially playing a significant role
These findings help to explain why leptin replacement does not completely reverse the neuroendocrine adaptations induced by weight loss 1, 3, 5 , since both GH and leptin play a role informing the brain about energy deficiency
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