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This comparison reflects our 2026 reading of the head-to-head trial data

Gastrointestinal: The adverse effects most frequently reported and most associated with discontinuation of semaglutide include nausea, vomiting, abdominal pain, constipation, and diarrhea

Clinicians should counsel reproductive-aged women on the potential reproductive implications of semaglutide use and emphasize adherence to recommended washout intervals before conception

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