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Sensitization occurred before LPS injection (4 h, day 1 and day 3), and LPS alone neither increased nociceptor excitability nor pain behavior, indicating that cartilage autoantibodies, not LPS or arthritis itself, drive pain behavior and sensorymotor dysfunction (Extended Data Fig

Briefly, approximately 2 10 5 cells were blocked with PBS containing 5% BSA (w/v) at RT for 15 min

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