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Setmelanotide is a disulfide cyclic synthetic peptide, eight amino acids long, capable of crossing the blood-brain barrier 37 where at its site of action in the hypothalamus, it can activate several melanocortin receptors 37

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A COA is a batch-specific lab report that documents the identity, purity, and quality control results for the production lot you receive

These include: Pernicious anaemia : An autoimmune condition where the body cannot produce intrinsic factor, preventing B12 absorption Crohn's disease or coeliac disease : Conditions affecting the ileum, where B12 is absorbed Previous gastric surgery : Including gastric bypass or removal of parts of the stomach or small intestine Atrophic gastritis : Chronic inflammation of the stomach lining Medication users may experience reduced B12 absorption