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In: Shoenfeld Y, Gershwin ME, Meroni PL, eds

Even with reduced appetite, weight gain can occur due to rebound hunger leading to overeating, slowed metabolism from long-term use, or bloating from water retention

Many providers recommend extending the titration period for patients over 50, spending more weeks at each dose level before stepping up, rather than following the most aggressive standard schedule

When patients ask about longterm risks, be transparent about what is known and unknown