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For instance, mechanical destruction of the cerebellum is quite different from severe cerebellar degeneration, although in both cases there could be a substantial loss of cerebellar functional capacity and cerebellar dysfunction manifested as cerebellar motor syndrome and/or CCAS as the underlying issues [6, 11]

Specifically, polymorphisms in ethanol-metabolizing genes like ADH1B and ALDH2 are closely linked to oxidative stress, DNA damage, and inflammatory responses induced by alcohol consumption