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Ssu72 deficiency significantly inhibited adipogenesis in preadipocytes from mice (Fig

Growth hormone secretion from the anterior pituitary gland is controlled by two primary opposing signals: Growth hormone-releasing hormone (GHRH): Produced by the hypothalamus, GHRH stimulates GH synthesis and release from pituitary somatotroph cells Somatostatin: Also produced by the hypothalamus, somatostatin inhibits GH release, creating a pulsatile pattern of secretion A third regulatory pathway involves ghrelin and growth hormone secretagogues (GHS) , which act through a separate receptor system (GHS-R1a) to amplify GH release independently of GHRH (1)

Meaningful weight loss typically begins within 48 weeks, with peak effects at 1224 months of consistent use

BMJ Open 14(11):e089783