does retatrutide affect testosterone and Testosterone: Interactions, Safety, and UK Guidance – Bolt Pharmacy When GLP-1 Medications Affect Libido:

Morning administration may be preferable for patients who experience nausea, as they can manage symptoms during waking hours when they can employ coping strategies such as eating small, low-fat meals, staying hydrated, or using anti-nausea medications if prescribed

[1] [2] Long-term cardiovascular outcomes and the full safety profile of this mechanism in humans remain to be established in ongoing Phase 3 trials

The most common options are single-hormone GLP-1 and dual-action GLP-1 + GIP medications

In my clinical experience treating patients with GLP-1 medications, nausea during the first few weeks is the primary reason people consider stopping treatment