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Table of Contents What Is a Calorie Deficit and How Does It Affect the Body How Long a Calorie Deficit Is Generally Safe to Maintain Signs That a Prolonged Calorie Deficit May Be Harming Your Health Risks of Staying in a Calorie Deficit for Too Long NHS and NICE Guidance on Safe and Sustainable Weight Loss When to Speak to a GP or Registered Dietitian Scientific References Frequently Asked Questions What Is a Calorie Deficit and How Does It Affect the Body A calorie deficit occurs when calorie intake falls below total daily energy expenditure, prompting the body to use stored glycogen then fat for energy, while also triggering metabolic adaptations including a reduced basal metabolic rate and increased hunger hormones

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Among these are the beta-cell hormone amylin and the intestinal L cell hormone glucagon-like peptide-1 (GLP-1)

SCFAs have been found to activate four different types of GPCRs, including GPR41/FFAR3, GPR43/FFAR2, GPR109A, and Olfr78 [51]