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Incidence of severe hypoglycemia was 1% b Hypoglycemia was more frequent when RYBELSUS was used in combination with insulin secretagogues (eg, sulfonylurea) or insulin - Patients may require a lower dose of the secretagogue or insulin to reduce the risk of hypoglycemia in this setting A cardiovascular outcomes trial (CVOT) compared RYBELSUS added to standard of care vs placebo added to standard of care Primary endpoint was the time to first occurrence of a 3-part composite outcome of major adverse cardiovascular events (MACE), which included cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke The total number of primary component MACE endpoints was 137 (61 [3.8%] with RYBELSUS and 76 [4.8%] with placebo) CV=cardiovascular

However, their muscle NAD + levels tended to decrease with age (Fig

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