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In summary, SIRT3 enhances FAO by deacetylating and activating CPT2, which subsequently alters the relative content of LC and PC in adipocytes

Although robust preclinical evidence indicates that modulation of ferroptosis attenuates myocardial and vascular injury, clinical translation is constrained by incomplete understanding of context-specific roles, the paucity of validated biomarkers, and the absence of targeted therapeutics with acceptable safety profiles

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