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Currently, multiple phase 3 programs evaluating disparate GLP-1 RAs (eg, semaglutide, brenipatide [GLP-GIP agonists]) are ongoing, with results expected to appear over the next 1 to 3 years (NCT07219953, NCT07286175, NCT07412756, NCT07410507)
Again, taking the correct type is really important (see above)
Larger and long-term studies are warranted to generate more evidence
Following the KEAP1 inactivation, the expression and the nuclear translocation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) are increased, which subsequently promotes the transcription of antioxidant proteins like superoxide dismutase 2 (SOD2) and heme oxygenase 1 (HO-1), and leads to the mitigation of synovial inflammation
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