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Under pathological conditions such as calcium overload, higher ROS, ATP depletion, or ischemic injury, the mPTP can open transiently or persistently, leading to dissipation of the mitochondrial membrane potential, matrix swelling, and rupture of OMM [38,39,40,41]

Some clock genes are reported to directly bind the SOD1 promoter, enhancing nocturnal antioxidant defense, or regulate NADPH-generating enzymes to maintain rhythmic reducing power [139]

Shah shares his personal journey from burnout, autoimmune disease, and multiple medications to reclaiming his health through nutrition, movement, functional medicine, and biomarker tracking