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Choose Ozempic (Semaglutide) If: You have type 2 diabetes and established cardiovascular disease semaglutide has a proven cardiovascular benefit (SUSTAIN-6 trial) You have pre-existing diabetic retinopathy requiring more gradual glucose reduction You have chronic kidney disease semaglutide has an approved kidney-protective indication Your insurance covers semaglutide but not tirzepatide Choose Mounjaro (Tirzepatide) If: Maximum weight loss is your primary goal the data consistently and significantly favours tirzepatide You have type 2 diabetes with persistently poor blood glucose control Your insurance or savings programme makes tirzepatide accessible at a similar cost You have PCOS with significant insulin resistance the dual GLP-1/GIP mechanism produces particularly meaningful improvements in HOMA-IR

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Cardiovasc Intervent Radiol 2006;29:1927.Google Scholar Gleason, A, Bishop, K, Xi, Y, Fetzer, DT