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The results showed that GHK-Cu significantly improved skin sagging, transparency and appearance, and reduced the depth of fine lines and wrinkles compared with placebo

doi:10.1016/j.clnesp.2020.03.008 Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A

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Our data show auto-AcT activity is used by SnCE1 to regulate important protein functions, i.e., affecting autoproteolytic processing needed for efficient cytosolic and mitochondrial distribution in the host cell and to stabilize the SnCE1 monomer, thereby improving its deSUMOylase activity as structurally tetramer formation and SUMO binding at the S1 site are mutually exclusive