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Dark areas on the neck, underarms, elbows, or face : These areas often develop pigmentation because of friction or hormonal factors

BBB dysfunction is considered a key mechanism through which peripheral inflammation contributes to CNS pathology in ASD, allowing inflammatory molecules and immune cells to infiltrate neural tissue and exacerbate neuroinflammation (Candelario-Jalil et al., 2022

Outcomes covered biologic/surrogate (e.g., proteinuria, estimated glomerular filtration rate [eGFR] slope) and hard endpoints (kidney failure, major cardiovascular events, fractures, mortality)

They must be reconstituted with a sterile solvent before use