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In xenografts derived from PDCs with high expression of VRK2, the growth of the tumor was markedly suppressed in the group that received combined treatment with APR-017 and IC261, followed by the group that received IC261 treatment, and barely altered in the APR-017 group (Fig

Under physiological conditions, the cyclic recruitment of primordial follicles and the gradual reduction in oocyte quality result in a year-by-year decrease in ovarian reserve, ultimately leading to its exhaustion after menopause

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However, larger trials have not consistently shown mortality benefit (Rank et al., Crit Care Med, 2000) [41]