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Eur J Intern Med (2006) 17:54550

This conformational shift activates G-proteins inside the cell, which then trigger a cascade of molecular events

I loved going to that Montreal Comedy Festival

The transition from episodic to chronic migraine involves changes in nociceptive thresholds and central sensitization, driven by factors such as high frequency of migraine attacks, overuse of acute medications, obesity, stress, female sex, psychiatric conditions, and low socioeconomic status (34)