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This is one of the best examples available of a direct pathway between the gut microbiome and disease caused by protein misfolding

Nat Chem Biol 12, 497503 (2016)

In one 2000 study, researchers found that 79 percent of patients with hypothyroidism (and 67 percent of those with hyperthyroidism) had muscle complaints, with 54 percent of those having muscle weakness and 42 percent having cramps