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Patients with a history of hypersensitivity reaction to other GLP-1 receptor agonist should not be started on semaglutide
When to seek medical attention: Persistent vomiting preventing adequate fluid intake Severe abdominal pain, particularly if localized to the upper right quadrant (potential gallbladder issues) Severe pain in the upper abdomen radiating to the back (possible pancreatitis) Signs of dehydration (dark urine, dizziness, decreased urination) Inability to tolerate any food or liquids for more than 24 hours Severe constipation with abdominal distension or vomiting (possible ileus/obstruction) Yellowing of skin/eyes with fever and abdominal pain Patients with significant vomiting or diarrhea should be monitored for signs of acute kidney injury, particularly those with pre-existing renal impairment or taking medications that affect kidney function
Perspectives in GLP-1 research: new targets
A study published in the European Journal of Clinical Investigation found that glutathione supplementation can improve immune response in individuals with deficiencies, as well as in older people, whose immune function tends to decline with age
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