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The absence of standardized criteria for ovarian dysfunction and poor responder classification limits generalizability across studies, complicating the identification of target populations ( 5.2 Recommendations 5.2.1 Pathway-centric trials Mitochondrial and Redox Pathways: Targeted interventions aimed at enhancing mitochondrial function and redox balance are critical for improving oocyte quality

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In reverse mode NET causes an efflux of the cytoplasmic pool of presynaptic norepinephrine into the synaptic cleft, where it can activate postsynaptic -1 and -1 receptors to elevate systemic vascular resistance and stimulate cardiac output (Vansal & Feller 1999

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