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Introduction The high-altitude (HA) environment, predominantly characterized by hypobaric hypoxia (HH), represents one of the most physiologically challenging conditions on Earth ( 2 ), triggering a range of physiological adaptations ( Transcriptome analysis is an efficient sequencing technology that reveals specific biological processes and molecular mechanisms in the pathogenesis of diseases by screening and analyzing differentially expressed genes (DEGs) and their functions ( The aims of this research were as follows: (1) to establish HACD mice model, which was evaluated by behavioral tests, pathological and biochemical alterations

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Evidence is mixed and context-dependent, so diet, training, and total calories still matter most