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Replacing FM with poultry by-products in gilthead seabream ( Sparus aurata ) diets increased both the abundance and diversity of the intestinal microbiota of the fish (Fontinha et al., 2021), and partial replacement of FM with a combined poultry by-product and vegetable protein meal increased the ratio of Firmicutes to Proteobacteria in GM of rainbow trout (Rimoldi et al., 2018b)

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Crucially, all of the aforementioned central pathological changes profoundly affect the brains interoceptive network, particularly the insular cortex (147, 181)