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An unresolved issue is whether GSH-mediated copper buffering primarily delays cuproptotic initiation or fundamentally determines the threshold for mitochondrial proteotoxic collapse

Some patients experience postcholecystectomy syndrome, characterized by diarrhea, bloating, or fat malabsorption, which occurs in approximately 10-15% of cases, though prevalence estimates vary

In future, we plan to use the RNAi (RNA interference) method both at the cellular and animal levels to further investigate in-depth about the mechanism, especially the network between ER stress and the NO system

Reducing dosage or pausing use is advised if symptoms persist