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In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

Trends Microbiol 13:111118 Averyanov AA, Lapikova VP (1990) Activated oxygen as a possible factor in the autoinhibition of spore germination of the fungus Pyricularia oryzae

Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy

GLP-1 RAs promote weight loss primarily by reducing appetite and improving metabolic regulation