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The pharmacy benefit manager Prime Therapeutics published an analysis last summer that highlights this ongoing challenge with respect to the real-world effectiveness over time of the GLP-1 drugs used to treat obesity: Most overweight or obese patients without diabetes stop treatment within the first few years

Instead, neuronal GLP-1Rs located outside the BBB primarily serve as peripheral targets for gut-derived or pharmacologically administered GLP-1 (Varin et al., 2019

This combination controls blood sugar, reduces appetite, and promotes weight loss