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In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions

doi: 10.1093/brain/awaa262 77 HankeyGJBlackerDJ

While the idea of a patch alternative to injections is appealing, current commercial products dont offer a scientifically valid substitute

Patients may start Amarasate during treatment with GLP-1 RAs (to try to stop suppression of the endogenous production) or when they discontinue them (to help boost natural production)