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A study performed in primary cultures of OFs from GO patients and control subjects demonstrated that quercetin exerts an inhibitory effect on fibroblasts proliferation and HA release, with no difference between GO and control fibroblasts ( in vivo studies are needed to confirm this hypothesis, also considering that quercetin seems to act through necrosis, which may worsen autoimmunity against orbital antigens due to antigen exposure to the immune system

An intradermal test dose is recommended before Cyanocobalamin Injection, USP is administered to patients suspected of being sensitive to this drug

IOM, 1998)

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