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Among the causes of cardiovascular disease, atherosclerosis is the underlying disorder in the majority of patients

For an excellent full text review of this anatomy and circuits for touch sensing, please see: Thank you to our sponsors AG1 (Athletic Greens): InsideTracker: Thesis: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Skin, Pain, Pleasure (00:01:50) Protocol 1: Maximizing Motivation (with Dopamine & Pleasure) (00:07:12) Sponsors (00:12:04) Pleasure & Pain, & Skin Sensors (00:18:13) Sensing Touch with Your Brain: Magnification of Feet, Hands, Lips, Face, Genitals (00:22:16) Two-Point Discrimination, Dermatomes (00:28:11) Thoughts & Genes That Make Physical Pain Worse (00:33:45) Expectations, Anxiety, & Pain Threshold (00:40:27) Protocol 2: Cold Sensing Is Relative

Thank you to our sponsors AG1 (Athletic Greens): InsideTracker: Thesis: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Social Bonding: Child-Parent, Romantic, Friendship, Breakups (00:02:55) Sponsors (00:07:08) Social Bonding as a Biological Process (00:10:03) Social Isolation (00:13:32) Social Homeostasis & Neural Circuits for Social Drive (00:18:55) Brain Areas & (Neuro)Chemistry of Social Drive (00:22:48) What is Social Homeostasis & Dopamine (00:27:00) When We Lack Social Interactions: Short- Versus Long-Term (00:28:10) Introverts & Extroverts (00:31:00) Good Versus Bad Social Interactions & Hierarchies (00:33:54) Loneliness & Dorsal Raphe Nucleus & Social Hunger (00:37:33) Tools (00:38:05) Socializing & Food Appetite: Crossover Craving (00:42:45) Falling in Love (00:45:05) Tools for Social Bonds: Merging Physiologies

TB-500 is a synthetic fragment of Thymosin Beta-4 whose core proposed action is the sequestering of G-actin to regulate actin polymerization the process behind cell migration in wound healing and which has been linked preclinically to angiogenesis and reduced inflammation [3] [4]