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(2020) discovered artesunate inhibited the growth of cultured Merkel cell polyomavirus (MCPyV)-positive MCC cell lines effectively, and artesunate-induced cell death in investigated MCC cell lines can be significantly reduced by ferrostatin-1, deferoxamine and rosiglitazone (an inhibitor of the ACSL4)

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One of these classes (class I ferroptosis-inducing compounds, erastin derivatives) inhibits GPX4 through the depletion of glutathione, and the other (class II ferroptosis-inducing compounds, RSL3 derivatives) inhibits GPX4 directly, without glutathione depletion

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