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Investigating differential responses based on patient demographics, genetic profiles, and specific pain conditions will also be crucial in developing personalized treatment strategies, thereby optimizing the therapeutic benefits of GLP-1R agonists for diverse patient populations
Placebo-corrected drug effects showed that GLP-1GIPLani solidly outperformed GLP-1Lani, GLP-1Tesa and GLP-1GIPTesa to further decrease body weight, fat mass and blood glucose (Extended Data Fig
Along with controlling glycemia and reducing insulin resistance, GLP-1RAs also reduce diabetic neuropathic pain by suppressing neuroinflammation in the spinal cord
Kiermayer et al
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