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The potential benefits of such treatment (long-term weight reduction, prevention of diabetes and diabetic complications, including cardiovascular events) need to be demonstrated in large clinical trials, but this earlier-stage population may provide unique chances to reveal benefits that cannot be shown at later stages, when the degree of tissue damage has advanced to an irreversible state

Most common steps to implement this combo can be discussed as: Start tirzepatide under clinical supervision, recognising the average ~10 kg+ loss potential and dose-response pattern

What does a 'GLP-1 Friendly' diet look like

Since tirzepatide already causes gastrointestinal side effects for some, combining it with NSAIDs might increase the risk of stomach irritation or ulcers