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Back McLean, BA, Wong, CK, Campbell, JE, et al (2021) 'Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation', Endocrine Reviews , 42/2, 101-32

Pregnant or breastfeeding women should also consult their healthcare provider before starting tirzepatide

The takeaway: berberine has a legitimate, research-backed role in supporting healthy blood sugar for people looking for a natural option, but it is not a diabetes treatment and should never replace prescribed medication

Metformin for diabetes is generally safe to continue