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DSIP (Delta Sleep-Inducing Peptide) is a small neuropeptide composed of nine amino acids with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from rabbit brains in the 1970s

Alleviation of TBI-Induced Inflammation Neuroinflammation is an important pathological cause of secondary TBI, which induces instant activation of innate immunity in brain tissue associated with impairment of the BBB, increases water content in the brain, and promotes the secretion of excitatory neurotransmitters, causing an imbalance in ion homeostasis and apoptosis, eventually leading to brain dysfunction [71]

However, these results need to be further validated in large clinical settings

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