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First, the majority of the studies referenced in the article were based on experimental animal and cell models, so the validity and safety of extrapolating the conclusions to clinical settings are limited

Cheng C, Hu J, Li Y, Ji Y, Lian Z, Au R, et al

Lancet Diabetes Endocrinol 11(4):282298 Wyne KL, Nair L, Schneiderman CP, Pinsky B, Flores OA, Guo D, Barger B, Tessnow AH (2023) Hypothyroidism prevalence in the United States: a retrospective study combining national health and nutrition examination survey and claims data

HK2 cells transfected with WT USP2 , but not the catalytically inactive USP2 C276A mutant, increased the protein level of TFRC and decreased TFRC ubiquitination (Fig