is glp-1 for diabetes GLP-1-based therapies type 2 diabetes: from single, dual and triple agonists to endogenous production and L-cell differentiation | Diabetology & Metabolic Syndrome Could GLP-1 Receptor Agonists Help

But the program focuses on three: Orforglipron (Foundayo), a once-daily tablet that can be taken by mouth without food or water and in clinical trials led to an 11% weight reduction in 16 months

The only reviews that exist are on its own website with no external links

Nat Rev Endocrinol (2012) 8(12):72842

(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux