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One of the older animal studies found it grew organs rather than the animal: However, the fractional weight of adrenals, gut, kidneys and spleen were significantly increased by LR3IGF-I, but again overall growth was not stimulated

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Furthermore, transcriptomic profiling of CD4 T cells from cerebrospinal fluid versus blood in MS patients identified CYP51A1 as a candidate gene implicated in disease-specific immune responses [92]

Interchangeability requires that a product is biosimilar to the reference product and the product must demonstrate that it can be expected to produce the same clinical results as the reference product in any given patient and, for products that are administered multiple times to an individual, the biologic and the reference biologic may be alternated or switched after one has been previously administered without increasing safety risks or risks of diminished efficacy relative to exclusive use of the reference biologic